The Reds were due to face Vitor Pereira's side on Saturday 19 April but the game will now take place a day later, on Sunday 20 April.
Kick-off has also been altered for the meeting in M16, to the 14:00 BST slot.
Ruben Amorim's side advanced to the last eight of the Europa League on Thursday and face Lyon in the quarter-finals.
The away leg is scheduled to take place in France on Thursday 10 April, at 20:00 BST.
The return game will be played exactly a week later at Old Trafford, on Thursday 17 April, meaning the Wolves fixture had to be moved back.
United take on Nottingham Forest, Manchester City and Newcastle United in the Premier League next month before Wolves' visit, while the trip to Bournemouth is touted for the final Sunday of the month - unless the Cherries make it past City and into the Emirates FA Cup semi-finals.
Amorim's men are back in action this Sunday, as we face Leicester City at the King Power Stadium. Click here for further details.