The necessity and challenges for developing Next-Generation Risk Assessment Approaches
Traditional toxicity testing by using animal models has served its purpose reasonably well. However, due to many challenges including testing of thousands of previously untested chemical contaminants, mixture aspects as well as changes in the types of chemicals and materials produced, there is a need for improvement of the existing risk assessment paradigm.
Next-Generation Risk Assessment (NGRA) based on New Approach Methodologies (NAMs) is commonly regarded as the way forward. Incorporating new scientific insights and innovative approaches into hazard assessment in a way that regulatory needs are adequately met is challenging. This includes difficulties that the biology of a complete mammalian organism has to be covered by a limited number of cellular assays but also regarding standardisation and validation.
What is this collection about?
Highlighting research on new approach methodologies, this Collection aims to address the need for improving the hazard assessment methods as well as the difficulties in developing the novel methods. This includes original articles as well as review articles, strategical or conceptual papers as well as reports on risk assessments done with NAM or on validation of alternative methods.
How can this collection help?
Our Top Collections like this one aim to support and promote high-quality science. They are led by Guest Editors who are experts in their fields, and supported by a dedicated team of Commissioning Editors, Managing Editors and In-House Editors at Springer Nature. Collection articles typically see higher citations, downloads, and Altmetric scores, and provide a one-stop-shop on a cutting-edge topic of interest.
Championing the New Approach Methodologies development
Dr. Philip Marx-Stoelting is serving at the German Federal Institute for Risk Assessment (BfR) as a scientific director.Dr. Gilles Rivière is serving at the French (ANSES) as senior toxicologist. They are both involved in several large European research projects on NAM development including PARC, where they are co-leading the work-package ‘hazard assessment’.As Guest Editors for Discover Toxicology, they are keen to see New Approach Methodologies in Toxicology highlighted on a global scale.
How can I submit my paper?
Visit the Collection page to find out more about this collection and submit your article.