Abstract
Surgical therapy of Peyronie’s disease is the gold standard for correction of the associated penile curvature. In patients with co-existing erectile dysfunction, not responding to medical/conservative treatment, penile prosthesis implantation is indicated and recommended. Severe residual curvature in these cases can be addressed by plaque incision and grafting. The novel collagen fleece TachoSil® (Corza Medical, MA, USA) has emerged as a reliable and robust graft for this purpose, with favorable results. Hatzichristodoulou was the first to publish his new technique of plaque incision and grafting with TachoSil® for residual curvature correction during penile prosthesis implantation in 2018 (PICS Technique). Since then, this technique was adopted and used by various surgeons. In the current narrative review all publications using this novel graft after plaque incision for residual curvature correction will be presented and respective results discussed. Moreover, the surgical technique will be highlighted in detail. The TachoSil® has self-adhesive properties which make it unique and the ideal graft for this indication. Results of the studies on this topic, that are available so far, are excellent. The technique is safe. However, data from more patients and even more long-term follow-up results of patients treated with this technique and graft are requested.
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References
Hatzichristodoulou G, Osmonov D, Kübler H, Hellstrom WJG, Yafi FA. Contemporary review of grafting techniques for the surgical treatment of Peyronie’s disease. Sex Med Rev. 2017;5:544–52.
ArticlePubMedGoogle Scholar
Hatzichristodoulou G. The PICS technique: a novel approach for residual curvature correction during penile prosthesis implantation in patients with severe Peyronie’s disease using the collagen fleece TachoSil. J Sex Med. 2018;15:416–21.
ArticlePubMedGoogle Scholar
Sokolakis I, Pyrgidis N, Ziegelmann MJ, Mykoniatis I, Köhler TS, Hatzichristodoulou G. Penile prosthesis implantation combined with grafting techniques in patients with Peyronie’s disease and erectile dysfunction: a systematic review. Sex Med Rev. 2022;10:451–9.
ArticlePubMedGoogle Scholar
Hatzichristodoulou GA. Novel approach for residual curvature correction during inflatable penile prosthesis implantation in patients with Peyronie’s disease: The PICS technique. Video J Prosth Urol. 2018;2:139.
Google Scholar
Hatzichristodoulou G, Gültekin MH, Özkara H, Akkus E. First worldwide correction of ventral Peyronie’s disease utilizing rigicon inflatable penile prosthesis combined with plaque incision & grafting with collagen fleece (PICS-Technique) for residual curvature. Int J Impot Res. 2025;37:33–6.
ArticlePubMedGoogle Scholar
Hatzichristodoulou G. Surgical therapy of Peyronie’s disease by partial plaque excision and Sealing of tunical defect with collagen fleece: the sealing technique. Video J Prosth Urol. 2016;2:076.
Google Scholar
Hatzichristodoulou G. Introducing the ventral sealing technique using collagen fleece for surgical therapy of patients with ventral Peyronie’s curvature: initial experience. Int J Impot Res. 2018;30:306–11.
ArticleCASPubMedGoogle Scholar
Hatzichristodoulou G, Fiechtner S, Pyrgidis N, Gschwend JE, Sokolakis I, Lahme S. Suture-free sealing of tunical defect with collagen fleece afer partial plaque excision in 319 consecutive patients with Peyronie’s disease: the sealing technique. J Urol. 2021;206:1276–82.
ArticlePubMedGoogle Scholar
Falcone M, Preto M, Ceruti C, Timpano M, Garaffa G, Sedigh O, et al. A comparative study between 2 different grafts used as patches after plaque incision and inflatable penile prosthesis implantation for end-stage Peyronie’s disease. J Sex Med. 2018;15:848–52.
ArticlePubMedGoogle Scholar
Fernández-Pascual E, Gonzalez-García FJ, Rodríguez-Monsalve M, Turo J, Martínez-Ballesteros C, Carballido J, et al. Surgical technique for complex cases of Peyronie’s disease with implantation of penile prosthesis, multiple corporeal incisions, and grafting with collagen fleece. J Sex Med. 2019;16:323–32.
ArticlePubMedGoogle Scholar
Farrell MR, Abdelsayed GA, Ziegelmann MJ, Levine LA. A comparison of hemostatic patches versus pericardium allograft for the treatment of complex Peyronie’s disease with penile prosthesis and plaque incision. Urology. 2019;129:113–8.
ArticlePubMedGoogle Scholar
Hatzichristodoulou G, Yang DY, Ring JD, Hebert KJ, Ziegelman MJ, Köhler TS. Multicenter experience using collagen fleece for plaque incision with grafting to correct residual curvature at the time of inflatable penile prosthesis placement in patients with Peyronie’s disease. J Sex Med. 2020;17:1168–74.
ArticlePubMedGoogle Scholar
Falcone M, Preto M, Peretti F, Gontero P, Pyrgidis N, Sokolakis I, et al. The use of collagen fleece to correct residual curvature during inflatable penile prosthesis implantation (PICS technique) in patients with complex Peyronie disease: a multicenter study. J Sex Med. 2023;14:229–35.
ArticleGoogle Scholar
Pyrgidis N, Sokolakis I, Hatzichristodoulou G. Intermediate-term results of TachoSil grafting to correct residual curvature during inflatable penile prosthesis implantation in patients with Peyronie’s disease. Int J Impot Res. 2023;35:647–50.
ArticlePubMedGoogle Scholar
Hatzichristodoulou G. Evolution of the surgical sealing patch TachoSil® in Peyronie’s disease reconstructive surgery: technique and contemporary literature review. World J Urol. 2020;38:315–21.
ArticlePubMedGoogle Scholar
Hatzichristodoulou G, Gschwend JE, Lahme S. Surgical therapy of Peyronie’s disease by partial plaque excision and grafting with collagen fleece: feasibility study of a new technique. Int J Impot Res. 2013;25:183–7.
ArticleCASPubMedGoogle Scholar
Anaissie J, Yafi FA. A review of surgical strategies for penile prosthesis implantation in patients with Peyronie’s disease. Transl Androl Urol. 2016;5:342–50.
ArticlePubMedPubMed CentralGoogle Scholar
Seyam R, Alhussain TO, Abualhasan AM, Kattan SA, Altaweel WM. Long-term histological and hemodynamic findings of repairing penile tunica albuginea defects with collagen fleece in dogs. Int J Impot Res. 2024. https://doi.org/10.1038/s41443-024-00934-2.
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Department of Urology, Martha-Maria St. Theresien Hospital, Nuremberg, Germany
Georgios Hatzichristodoulou
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Georgios Hatzichristodoulou
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Conception and design of the study: GH. Data acquisition: GH. Analysis and interpretation of data: GH. Drafting the manuscript: GH. Style revision: GH. The author revised the manuscript and read and approved the version submitted.
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Correspondence to Georgios Hatzichristodoulou.
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Hatzichristodoulou, G. Simultaneous penile prosthesis placement and collagen fleece (TachoSil) grafting. Where do we stand in 2024?. Int J Impot Res (2025). https://doi.org/10.1038/s41443-025-01046-1
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Received:20 October 2024
Revised:14 February 2025
Accepted:10 March 2025
Published:18 March 2025
DOI:https://doi.org/10.1038/s41443-025-01046-1
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