A method infers tension from spatial transcriptomic data on single cells in tissue context.
This is a preview of subscription content, access via your institution
Access options
Access through your institution
Change institution
Buy or subscribe
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Learn more
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Learn more
Buy this article
Purchase on SpringerLink
Instant access to full article PDF
Buy now
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Log in
Learn about institutional subscriptions
Read our FAQs
Contact customer support
Fig. 1: Pipeline for integration of data on morphology, state and mechanics of single cells in issue context.
References
Pijuan-Sala, B. et al. Nature 566, 490–495 (2019).
ArticleCASPubMedPubMed CentralGoogle Scholar
Nowotschin, S. et al. Nature 569, 361–367 (2019).
ArticleCASPubMedPubMed CentralGoogle Scholar
Lohoff, T. et al. Nat. Biotechnol. 40, 74–85 (2022).
ArticleCASPubMedGoogle Scholar
Hallou, A., He, R., Simons, B. D. & Dumitrascu. B. Nat. Methodshttps://doi.org/10.1038/s41592-025-02618-1 (2025).
Rauzi, M., Verant, P., Lecuit, T. & Lenne, P. F. Nat. Cell Biol. 10, 1401–1410 (2008).
ArticleCASPubMedGoogle Scholar
Samarage, C. R. et al. Dev. Cell 34, 435–447 (2015).
ArticleCASPubMedGoogle Scholar
Yamashita, S., Tsuboi, T., Ishinabe, N., Kitaguchi, T. & Michiue, T. Sci. Rep. 6, 28535 (2016).
ArticlePubMedPubMed CentralGoogle Scholar
Noll, N., Streichan, S. J. & Shraiman, B. I. Phys. Rev. X 10, 011072 (2020).
CASPubMedPubMed CentralGoogle Scholar
Dahmann, C., Oates, A. C. & Brand, M. Nat. Rev. Genet. 12, 43–55 (2010).
ArticleGoogle Scholar
Batlle, E. & Wilkinson, D. G. Cold Spring Harb. Perspect. Biol. 4, a008227 (2012).
ArticlePubMedPubMed CentralGoogle Scholar
Download references
Author information
Authors and Affiliations
Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Alexandre Francou, Woonyung Hur & Anna-Katerina Hadjantonakis
Center for Studies in Physics and Biology, The Rockefeller University, New York, NY, USA
Woonyung Hur
Authors
Alexandre Francou
View author publications
You can also search for this author inPubMedGoogle Scholar
2. Woonyung Hur
View author publications
You can also search for this author inPubMedGoogle Scholar
3. Anna-Katerina Hadjantonakis
View author publications
You can also search for this author inPubMedGoogle Scholar
Corresponding author
Correspondence to Anna-Katerina Hadjantonakis.
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
Reprints and permissions
About this article
Check for updates. Verify currency and authenticity via CrossMark
Cite this article
Francou, A., Hur, W. & Hadjantonakis, AK. Marrying mechanics with spatial transcriptomics. Nat Methods (2025). https://doi.org/10.1038/s41592-024-02491-4
Download citation
Published:19 March 2025
DOI:https://doi.org/10.1038/s41592-024-02491-4
Share this article
Anyone you share the following link with will be able to read this content:
Get shareable link
Sorry, a shareable link is not currently available for this article.
Copy to clipboard
Provided by the Springer Nature SharedIt content-sharing initiative