Cellular metabolism produces reactive metabolites as both main and side products, requiring recycling pathways to detoxify these products. A study uncovers a recycling pathway that protects vitamin B12 from inactivating covalent modification.
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Fig. 1: CLYBL was identified as a malyl-CoA thioesterase that prevents malyl-CoA inhibition of methylmalonyl-CoA mutase.
References
Griffith, C. M. et al. Nat. Chem. Biol.https://doi.org/10.1038/s41589-025-01857-9 (2025).
ArticleGoogle Scholar
Wagner, G. R. et al. Cell Metab. 25, 823–837.e8 (2017).
ArticleCASPubMedPubMed CentralGoogle Scholar
Trefely, S., Lovell, C. D., Snyder, N. W. & Wellen, K. E. Mol. Metab. 38, 100941 (2020).
ArticleCASPubMedPubMed CentralGoogle Scholar
Naquet, P., Kerr, E. W., Vickers, S. D. & Leonardi, R. Prog. Lipid Res. 78, 101028 (2020).
ArticleCASPubMedPubMed CentralGoogle Scholar
Karjalainen, M. K. et al. Nature 628, 130–138 (2024).
ArticleCASPubMedPubMed CentralGoogle Scholar
Shen, H. et al. Cell 171, 771–782.e11 (2017).
ArticleCASPubMedPubMed CentralGoogle Scholar
Ruetz, M. et al. Science 366, 589–593 (2019).
ArticleCASPubMedPubMed CentralGoogle Scholar
Khan, A. et al. Nat. Genet. 56, 1614–1623 (2024).
ArticleCASPubMedPubMed CentralGoogle Scholar
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Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA
Adam Chatoff & Nathaniel W. Snyder
Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA
Adam Chatoff & Nathaniel W. Snyder
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Chatoff, A., Snyder, N.W. Recycling for a cleaner metabolism. Nat Chem Biol (2025). https://doi.org/10.1038/s41589-025-01852-0
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Published:19 March 2025
DOI:https://doi.org/10.1038/s41589-025-01852-0
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