Dutch star comes off the bench at half-time to score twice and put Nick Cushing's side in control of their Champions League quarter-final.
Manchester City started the game brightly with Mary Fowler at the heart of everything early on for the hosts after their League Cup defeat to Chelsea at the weekend
Lily Murphy was also causing Chelsea a few problems down the left flank as City dominated the first half but lacked the cutting edge in attack to find the breakthrough.
City boss Nick Cushing sent on Vivianne Miedema at half-time in search of goal and it proved an excellent change as the 28-year-old went on to break the deadlock on the hour.
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Fowler's cross was headed goalwards by Laia Aleixandri and parried onto the bar by Hampton, only for the ball to fall kindly to an unmarked Miedema at the far post to knock home.
Chelsea ramped up the pressure late on, as Mayra Ramirez saw a goal disallowed for offside and substitute Johanna Rytting Kaneryd rattled the frame of the goal with a powerful shot.
Yet it was the hosts who doubled their lead in the dying minutes. Kerolin drove down the right again before playing the ball in to Miedema to sweep home her second of the night and put Manchester City in control of the tie ahead of the return at Stamford Bridge.
GOAL rates Manchester City's players from the Joie Stadium