Rats were divided into groups and treated with azithromycin daily for a certain period. Some groups also received either gallic acid or glycyrrhetinic acid before or after azithromycin administration. The rats were monitored for changes in oxidative stress markers and inflammatory responses in the liver. Additionally, biochemical markers in blood and liver tissue were measured to assess the extent of liver damage.
Results:
The results showed that rats treated with gallic acid or glycyrrhetinic acid exhibited significant improvement in liver function compared to those treated with azithromycin alone. There was a marked reduction in oxidative stress markers (such as free radicals) and inflammation in the liver. Both gallic acid and glycyrrhetinic acid enhanced antioxidant enzyme levels, helping to reduce oxidative damage.
Positive Effects:
- Reduction of Oxidative Stress: Gallic acid and Glycyrrhetinic acid reduced the production of free radicals that damage liver cells, thus minimizing the harm caused by Azithromycin.
- Decrease in Inflammation: Both compounds helped to reduce inflammatory responses in the liver, promoting liver tissue protection.
- Improvement in Liver Function: Treatment with gallic acid and glycyrrhetinic acid led to noticeable improvement in liver function markers, indicating that these compounds could help protect the liver from Azithromycin-induced damage.
The findings suggest that gallic acid and glycyrrhetinic acid may offer a protective effect against azithromycin-induced liver damage in rats. The discovery could have potential applications in preventive medicine and in treating liver toxicity caused by pharmaceutical drugs, suggesting these natural compounds may be useful in improving liver health.