Brazil have not beaten the Argentines in six years, a run that extends to 16 years for matches held in Argentina, who lead the South American qualifying table with 28 points, six ahead of second-placed Ecuador and seven clear of Brazil in third.
If Bolivia fail to beat Uruguay in Tuesday's earlier match Argentina will be guaranteed a place at the 2026 World Cup in the Mexico, Canada and the US with four games left. Otherwise they can clinch a spot with a draw against Brazil.
Brazil coach Dorival Jr wants the team to can prove their critics wrong by ending their winless run against their old foes.
A late 2-1 victory over Colombia on Thursday saw the Seleção return to winning ways after successive draws, Dorival believes Tuesday's showdown could be the ideal situation to prove his side are still a force to be reckoned with.
“We will face the reigning champions of the world and South America, the most successful team in the world in recent years and we will go out there to win, to play our best football and beat them at their ground,” Dorival said on Monday.