Transferring cell cultures between different scales, commonly known as scale-up or scale-down, presents significant challenges. This process often involves extensive trial and error to accurately predict the physical characterization parameters required for bioreactors. Manual scaling is not only time-consuming but also prone to errors, potentially causing delays in transitioning from small-scale to pilot-level production. To address these challenges, Cytiva has developed the Bioreactor Scaler, a sophisticated software platform designed to predict optimal bioreactor settings. This innovative tool enables users to conduct in silico experiments, which help define crucial process parameters.
In a detailed case study, scientists utilized Bioreactor Scaler Pro, an advanced version of the software, to streamline the scale-up process from milliliter-scale to liter-scale production. Discover how this approach significantly expedited the program's progression to toxicology stage testing and GMP production, ultimately advancing to pivotal clinical studies.