With Aji Alese already sidelined having suffered a broken leg in January, Sunderland will be without Dennis Cirkin for the next two to three weeks and Leo Hjelde has also been ruled out of tomorrow's game.
Cirkin was forced to withdraw from the England Under-21 squad with a hamstring injury and could now miss the next four Sunderland games.
Hjelde is expected to be back for next weekend's trip to West Brom, but with the former Leeds and Celtic man missing tomorrow's game, Le Bris will be forced to tinker with his defence.
There was better news on the injury front, with Trai Hume available to play tomorrow. Hume left the Northern Ireland camp early during the international break because of a hip problem, but it's an issue the right-back has been managing for a number of weeks and will continue to do so between now and the end of the season.
**RECOMMENDED READING:**
With Hume passed fit, Le Bris could move Luke O'Nien to left-back tomorrow and partner Chris Mepham with Jenson Seelt. Dan Ballard remains a few weeks away from being fit to return.
"It's probably two or three weeks more on Dennis," said Le Bris.
"Yes (it's a blow) but the season is like that with many injuries and opportunities for other players. We'll manage a situation like that.
"Leo shouldn't be available for Saturday, but next week (he will be). We'll find a solution."
Le Bris expects Enzo Le Fee to resume training next week, but Salis Abdul Samed is still "two to three weeks away".
Le Fee has missed the last four Championship games, but could be in contention to return against either West Brom or Norwich early next month.
Samed has endured a frustrating injury-riddled campaign and the loanee has started only two league games.
Liverpool loanee Jayden Danns is not yet ready to link-up with Sunderland and Le Bris admitted time is quickly running out for the [Black Cats](http://www.thenorthernecho.co.uk/sport/football/sunderland) and the striker.
Danns joined Sunderland on loan from Liverpool on deadline day but a back injury was detected during his medical and he returned to his parent club for treatment.
The hope was that the young striker would be fit enough to join up with Sunderland at some stage and play a part in their run-in.
But the Black Cats have just eight games to play and Danns is yet to train with Le Bris' squad.
Asked whether it's getting to the stage where Sunderland will have to admit defeat on the Danns situation, Le Bris said: "We are not at this point right now but the season is running so it will be difficult. We don't know exactly."