The quake has wreaked havoc in five of Myanmar's cities and towns. Buildings collapsed in Mandalay.
A railway bridge and a road bridge on the Yangon-Mandalay Expressway have also collapsed, state media reported.
Eyewitness accounts talk of chaos: one resident said they "witnessed a five-storey building collapse in front of [their] eyes."
The ruling military junta has declared emergency in Sagaing Region, Mandalay Region, Magway Region, northeastern Shan State, Nay Pyi Taw Council Area, and Bago Region.