A near-infrared optogenetic system was developed for the controlled expression of therapeutics in engineered oncolytic bacteria, demonstrating significant anti-tumor efficacy in multiple tumor mouse models. This approach offers a non-invasive, customizable method for targeted solid tumor therapy and has broader applications in engineered living therapeutics.
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Fig. 1: NETMAP-engineered bacteria for cancer therapy.
References
Liu, B., Zhou, H., Tan, L., Siu, K. T. H. & Guan, X.-Y. Exploring treatment options in cancer: tumor treatment strategies. Sig. Transduct. Target. Ther. 9, 175 (2024). A review article that presents a comprehensive overview of emerging cancer therapies.
Google Scholar
Zhou, S., Gravekamp, C., Bermudes, D. & Liu, K. Tumour-targeting bacteria engineered to fight cancer. Nat. Rev. Cancer 18, 727–743 (2018). A review article that presents the potential of engineered bacteria as a targeted delivery platform for cancer therapies.
CASPubMedPubMed CentralGoogle Scholar
Gurbatri, C. R., Arpaia, N. & Danino, T. Engineering bacteria as interactive cancer therapies. Science 378, 858–864 (2022). A review article that discusses the use of synthetic biology in optimizing bacterial therapies for cancer, focusing on enhancing therapeutic safety and effectiveness through engineered bacterial systems.
CASPubMedPubMed CentralGoogle Scholar
Gourinchas, G., Vide, U. & Winkler, A. Influence of the N-terminal segment and the PHY-tongue element on light-regulation in bacteriophytochromes. J. Biol. Chem. 294, 4498–4510 (2019). This paper reports the light-regulation mechanisms of chimeric photosensitive protein PadC4, which is an essential aspect of the NETMAP system.
CASPubMedPubMed CentralGoogle Scholar
Wilksch, J. J. et al. MrkH, a novel c-di-GMP-dependent transcriptional activator, controls Klebsiella pneumoniae biofilm formation by regulating type 3 fimbriae expression. PLoS Pathog. 7, e1002204 (2011). This paper reports that MrkH is a c-di-GMP-dependent transcriptional activator in Klebsiella pneumoniae.
CASPubMedPubMed CentralGoogle Scholar
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This is a summary of: Qiao, L. et al. Engineered bacteria for near-infrared light-inducible expression of cancer therapeutics. Nat. Cancer https://doi.org/10.1038/s43018-025-00932-3 (2025).
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Near-infrared optogenetic engineering of bacteria for cancer therapy. Nat Cancer (2025). https://doi.org/10.1038/s43018-025-00931-4
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Published:31 March 2025
DOI:https://doi.org/10.1038/s43018-025-00931-4
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