Proton pump inhibitors, commonly prescribed for excessive gastric acid secretion, may lead to unexpected side effects. Now a chemoproteomic method enables a comprehensive profiling of their off-target interactions, offering valuable insights into their mechanism of action in living cells.
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Fig. 1: Reactivity-based protein profiling of rabeprazole uncovers potential off-target.
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Authors and Affiliations
Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
Linghao Kong & Chu Wang
Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
Linghao Kong & Chu Wang
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Linghao Kong
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Kong, L., Wang, C. Secret action of gastric acid controlling drug. Nat. Chem. (2025). https://doi.org/10.1038/s41557-025-01788-x
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Published:01 April 2025
DOI:https://doi.org/10.1038/s41557-025-01788-x
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