The TAILORED-AF trial used artificial intelligence (AI)-guided mapping to enhance catheter ablation in persistent atrial fibrillation and demonstrated reductions in recurrent atrial fibrillation, but the net clinical benefit remains unclear.
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Fig. 1: TAILORED-AF protocol.
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Authors and Affiliations
Duke University Medical Center, Durham, NC, USA
Zak Loring & Jonathan P. Piccini
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Zak Loring & Jonathan P. Piccini
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Zak Loring
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2. Jonathan P. Piccini
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Correspondence to Jonathan P. Piccini.
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Z.L. is supported by grants from the Department of Veterans Affairs and Boston Scientific, and serves as a consultant for Huxley Medical and Boston Scientific. J.P.P. is supported by R01AG074185 from the National Institutes of Aging; receives grants for clinical research from Abbott, the American Heart Association, Boston Scientific, iRhythm and Philips; and serves as a consultant to Abbott, ABVF/Symkardia, Bayer, Kardium, Medtronic, Milestone Pharmaceuticals, Novartis, Sanofi, Philips and Up-to-Date.
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Loring, Z., Piccini, J.P. TAILORing AI-guided treatment for atrial fibrillation. Nat Med (2025). https://doi.org/10.1038/s41591-025-03611-z
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Published:02 April 2025
DOI:https://doi.org/10.1038/s41591-025-03611-z
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