Disruption of the enzyme O-GlcNAc transferase in mouse embryonic stem cells unleashes the activity of TET enzymes, which cause genome-wide decreases in DNA methylation and increases in DNA hydroxymethylation. This leads to de-repression of transposable elements, as well as the activation of some nearby genes.
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Fig. 1: OGT restrains TET activity in heterochromatin.
References
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This is a summary of: Sepulveda, H. et al. OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-025-01505-9 (2025).
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O-GlcNAc transferase is a key regulator of DNA methylation and transposon silencing. Nat Struct Mol Biol (2025). https://doi.org/10.1038/s41594-025-01507-7
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Published:02 April 2025
DOI:https://doi.org/10.1038/s41594-025-01507-7
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