As the manager [had revealed in his pre-match](https://www.cpfc.co.uk/news/first-team/glasners-pre-southampton-updates-on-squad-fitness/) press conference, Chris Richards misses the trip to the South Coast with a calf injury.
The defender is replaced in the side by **Nathaniel Clyne**, who made 104 appearances across three seasons with the Saints between 2012 and 2015.
Otherwise, Palace are unchanged from the side which saw off Fulham 3-0 at Craven Cottage on Saturday to advance to the FA Cup semi-finals.
On the bench, **Joel Ward** – having recovered from long-term injury – makes his first appearance in a matchday squad since late August, with **Matheus França** also making his second appearance in a Premier League matchday squad this season.
**Palace:** Henderson (GK), Clyne, Lacroix, Guéhi, Muñoz, Lerma, Wharton, Mitchell, Sarr, Mateta, Eze.
**Subs:** Turner (GK), Ward, Chilwell, Kporha, Devenny, Kamada, Esse, França, Nketiah.