Bruno Fernandes is tasked with starting in a deeper midfield position, alongside European competition past master Casemiro, who scored in both legs of the semi-final against this stadium's hosts Athletic Club.
Amad and Mason Mount will operate behind centre-forward Rasmus Hojlund.
It means there are a number of excellent options off the bench, including forwards Alejandro Garnacho and Joshua Zirkzee, plus defender Diogo Dalot, who has been out since the Premier League home contest with Wolves, over a month ago. Jonny Evans's last minutes came when he scored against Spurs in the Carabao Cup last December.
All in all, it is just one change from the XI that started against Chelsea last time out, with Yoro replacing Victor Lindelof.