Wales suffered a dramatic 4-3 World Cup qualifying defeat to Belgium as their incredible comeback from three goals down eventually proved in vain.
Kevin De Bruyne was the Belgium match-winner two minutes from time to deny Wales a precious point in Brussels.
Belgium had seized complete control inside 27 minutes as Romelu Lukaku, with a controversial penalty, Youri Tielemans and Jeremy Doku silenced the loud 4,500-strong following from Wales.
But Harry Wilson gave Wales hope from the spot on the stroke of half-time, and cool finishes from Sorba Thomas and Brennan Johnson turned the tie on its head.
Almost every goal had a laborious VAR check and a late Lukaku effort was chalked off – resulting in both Wales manager Craig Bellamy and his Belgium counterpart Rudi Garcia being booked – but there was no saving the visitors as De Bruyne volleyed home at the far post.
North Macedonia sit a point clear of Wales after a first-half goal from Aleksandar Trajkovski secured a 1-0 win away to Kazakhstan.
Luciano Spalletti finished his spell as Italy manager with a 2-0 win over Moldova to get their first points of the World Cup qualifying campaign.
Former Napoli boss Spalletti had announced on Sunday that the Group I fixture in Reggio Emilia would be his last, having seen his side slump to a 3-0 defeat away Norway in their opening game.
Italy broke the deadlock five minutes before half-time through Giacomo Raspadori's strike from the edge of the penalty area and Andrea Cambiaso added another soon after the restart.
Norway strengthened their position at the top of the table with a 1-0 win away over Estonia to maintain their perfect start through four games. Manchester City forward Erling Haaland got the only goal just after the hour.
Croatia thrashed the Czech Republic 5-1 in Osijek to make it two wins from two in Group L.
After Manchester City defender Josko Gvardiol saw his early goal from a free-kick ruled out for offside, Andrej Kramaric broke the deadlock three minutes before half-time.
Czech captain Tomas Soucek headed in an equaliser just before the hour from a corner.
Luka Modric, though, swiftly put Croatia back in front from the spot with Ivan Perisic adding a third in the 68th minute.
Croatia – who had thumped Gibraltar 7-0 on Friday – then put the result beyond doubt with two goals in the space of three minutes. Ante Budimir converted another penalty before Kramaric slotted in a fifth.
The Czech Republic remain top, having suffered a first loss after three straight wins.
The Faroe Islands came from behind to beat Gibraltar 2-1 in Torshavn with a late goal from Patrik Johannesen.
Watch Luxembourg v Republic of Ireland on Tuesday from 7.30pm on RTÉ2 and RTÉ Player. Follow a live blog on rte.ie/sport and the RTÉ News app.
Listen to the RTÉ Soccer podcast on Apple Podcasts, Spotify or wherever you get your podcasts.