Eddie Howe has named a Newcastle starting XI with mixed experience in it.
Alexander Isak is of course missing with ongoing speculation surrounding his future but goalkeeper Aaron Ramsdale makes his debut after joining from Southampton.
Newcastle XI: Ramsdale, Hall, Schar, Targett, Krafth, Osula, Murphy, Burn, Guimaraes, Park, Miley.
Subs: Ruddy, Gillespie, Kool, Murphy, Heffernan, Harrison, Bailey, Charlton, Sanusi, Shahar, Neave.
For Espanyol, their bench has a somewhat familiar name on it with Tyrhys Dolan.
The 23-year-old left Championship side Blackburn Rovers upon the expiry of his contract to join the La Liga side.
Espanyol XI: Dmitrovic, El Hilali, Rubio, Cabrera, Romero, Pol Lazano, Exposito, Sanchez, Rocha, Puada, Roberto.
Subs: Fortuno, Calero, Milla, Carreras, Ramon, Bauza, Tristan, Hinojo, Dolan, Garcia, Terrats, Salinas.