Real Madrid head coach Xabi Alonso is set to hand La Liga debuts to Trent Alexander-Arnold, Dean Huijsen and Alvaro Carreras in Tuesday's La Liga clash with Osasuna.
Franco Mastantuono is also in line to make his debut after officially completing a move from River Plate, but the Argentina international is likely to be used off the bench.
Jude Bellingham and Endrick are out of the match through injury, while Ferland Mendy and Eduardo Camavinga are likely to miss out due to fitness issues.
Los Blancos will also be unable to call upon Antonio Rudiger, as the suspension that he picked up in the latter stages of last season has carried into the new campaign.
Dani Ceballos is being linked with a move away from the Spanish capital, but he may be needed in the middle of midfield if Federico Valverde is unable to shake off a minor injury, while Arda Guler could also operate in that area.
Vinicius Junior and Kylian Mbappe are both set to play in the final third, but Rodrygo is not expected to start amid the speculation surrounding his future.
Brahim Diaz could instead feature in the front three, with Mastantuono an option off the bench.
Eder Militao is set to feature from the first whistle, and the Brazilian will be hoping for an injury-free campaign considering his fitness issues in recent seasons.
Real Madrid possible starting lineup: Courtois; Alexander-Arnold, Militao, Huijsen, Carreras; Guler, Tchouameni, Valverde; Brahim, Mbappe, Vinicius
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