Manchester United head coach Ruben Amorim and Arsenal manager Mikel Arteta have both confirmed their starting sides for Sunday's Premier League affair at Old Trafford.
There are debuts for Matheus Cunha and Bryan Mbeumo, with both players starting in the Man United attack, but fellow new signing Benjamin Sesko is on the bench for the 20-time English champions.
Diogo Dalot is given the nod as the right-sided wing-back, with Patrick Dorgu on the left, while Casemiro and Bruno Fernandes are set to operate in central midfield.
Andre Onana is also a notable absentee for the Red Devils, with the Cameroon international not ready to play due to a hamstring injury which has sidelined him during pre-season.
Manchester United's Matheus Cunha on July 19, 2025
Cunha, Mbeumo start for Man United against Arsenal
The goalkeeper's absence is not believed to be related in any way to his future, with Man United said to be keen to sign a new stopper before the summer transfer window closes for business.
Altay Bayindir, who is also being linked with a departure, instead features between the sticks.
There is also no space in the Red Devils squad for Rasmus Hojlund, with the Denmark international widely expected to leave Old Trafford before the end of the market.
Hojlund is keen to stay at Man United and fight for his spot despite the arrival of Sesko, but his absence from the squad against Arsenal has sent a clear transfer message.
Man United are also missing Lisandro Martinez and Noussair Mazraoui due to injury problems, but Joshua Zirkzee is on the bench, with the Dutchman recovering from a problem which has sidelined him during pre-season.
Arsenal's Viktor Gyokeres pictured on August 6, 2025
Gyokeres makes Arsenal debut at Old Trafford
As for Arsenal, Viktor Gyokeres starts through the middle, while there is also a Gunners debut for Martin Zubimendi, who has arrived from Real Sociedad during this summer's transfer window.
Head coach Mikel Arteta had some big decisions to make in the full-back positions, and Ben White and Riccardo Calafiori are given the nod over Jurrien Timber and Myles Lewis-Skelly.
Declan Rice is expected to play further forward this season due to the arrival of Zubimendi, while Gabriel Martinelli and Bukayo Saka will join Arsenal's new striker Gyokeres in the front three.
Fellow new arrivals Yerson Mosquera, Noni Madueke and Kepa Arrizabalaga start on the bench for the visitors to Old Trafford.
Man United starting XI: Bayindir; Yoro, De Ligt, Shaw; Dalot, Casemiro, Fernandes, Dorgu; Mount, Cunha, Mbeumo
Subs: Heaton, Fredricson, Heaven, Maguire, Mainoo, Ugarte, Amad, Sesko, Zirkzee
Arsenal starting XI: Raya; White, Saliba, Gabriel, Calafiori; Zubimendi, Rice, Odegaard; Saka, Gyokeres, Martinelli
Subs: Kepa, Mosquera, Timber, Lewis-Skelly, Merino, Nwaneri, Trossard, Madueke, Havertz
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