The Toon teenagers will host their Leicester City counterparts on Tuesday, 26th August in their opening group fixture, with kick-off set at 1pm (BST) before facing an away trip to Aston Villa on Saturday, 4th November (kick-off 11am GMT).
Chris Moore's side will then welcome Liverpool to Tyneside, with their final Group B fixture taking place on Saturday, 22nd November. Kick-off is set at 11am (GMT).
Teams must finish top of their respective group or be the best second-placed team in the competition to qualify for the quarter-finals.
Venues for the Under-18 Premier League Cup fixtures will be confirmed on **newcastleunited.com** in due course.