There are huge question marks over the 40-year-old’s future following Wednesday night’s cup embarrassment at Grimsby Town.
Coupled with his terrible league record since taking over at United, winning only seven of his 29 games, this could be a huge opportunity for the Clarets to take a big scalp of one of the so-called big teams early into the season.
Scott Parker’s side come into the game full of confidence after bouncing back from their opening day defeat to Tottenham by beating Sunderland 2-0 last Saturday.
Jordan Beyer, Connor Roberts and Zeki Amdouni all remain sidelined, but Burnley are otherwise looking pretty healthy after a handful of players got some much-needed minutes under their belts in the cup in midweek.
With that in mind, here’s how we think the Clarets will line up at Old Trafford:
While there's uncertainty over who will start in goal for United, Dubravka is guaranteed to be Burnley's number one against his former loan club (Photo by Matt McNulty/Getty Images)
1. GK - Martin Dubravka
While there's uncertainty over who will start in goal for United, Dubravka is guaranteed to be Burnley's number one against his former loan club (Photo by Matt McNulty/Getty Images) Photo: Matt McNulty
Does Parker stick with Bruun Larsen, who isn't a natural wing-back? Or bring back Oliver Sonne, who started against Spurs? Bruun Larsen will be the fresher after being rested in midweek (Photo by Matt McNulty/Getty Images)
2. RWB - Jacob Bruun Larsen
Does Parker stick with Bruun Larsen, who isn't a natural wing-back? Or bring back Oliver Sonne, who started against Spurs? Bruun Larsen will be the fresher after being rested in midweek (Photo by Matt McNulty/Getty Images) Photo: Matt McNulty
Walker's pace and recovery runs, as well as his experience, will be key if Burnley are to pick up a result (Photo by Lewis Storey/Getty Images)
3. CB - Kyle Walker
Walker's pace and recovery runs, as well as his experience, will be key if Burnley are to pick up a result (Photo by Lewis Storey/Getty Images) Photo: Lewis Storey
The Swede enjoyed an excellent game against Sunderland last week, but is likely to be tested by the likes of Mbuemo and Cunha (Photo by Justin Setterfield/Getty Images)
4. CB - Hjalmar Ekdal
The Swede enjoyed an excellent game against Sunderland last week, but is likely to be tested by the likes of Mbuemo and Cunha (Photo by Justin Setterfield/Getty Images) Photo: Justin Setterfield