Rest: Viktor Gyokeres
Arsenal Football Newsletter
The pair picked up injuries during Arsenal’s 1-0 win over Crystal Palace on Sunday.
Saliba was forced to come off at half-time. Martinelli finished the match, but limped down the tunnel following the full-time whistle.
Mikel Arteta has confirmed the pair will now miss Wednesday’s match at home to Brighton, and he is unsure when they will return.
“[Saliba] is out,” said Arteta. “We are assessing him, but he won’t be involved this match.
“It looks as well that [Martinelli] is going to be out. We have to, again, do some more tests and see the extent of the injury. But this game is going to be too early for him.”
Arsenal have received a boost, though, as Bukayo Saka, Declan Rice and Riccardo Calafiori are all fit.
Saka was struggling with illness before Sunday’s game against Palace and came off just after the hour mark.
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Calafiori and Rice were both substituted before the end of the match due to knocks.
The trio are all available to face Brighton, but Arteta is expected to rotate his team.
Kepa Arrizabalaga is due to start in goal and make his second appearance of the season.
Ben White, Cristhian Mosquera and Myles Lewis-Skelly should come into the defence, while there could be a full debut for Piero Hincapie.
Ahead of them, Ethan Nwaneri and Christian Norgaard are likely to play in midfield. Mikel Merino could lead the line if Arteta decides to rest striker Viktor Gyokeres.
Max Dowman, who is only 15 years old, is a contender to be in the squad.
Arsenal predicted XI (4-3-3): Arrizabalaga; White, Mosquera, Hincapie, Lewis-Skelly; Nwaneri, Norgaard, Eze; Saka, Merino, Trossard
Injured: Havertz (knee), Jesus (knee), Madueke (knee) Martinelli (thigh), Odegaard (knee) and Saliba
Time and date: 7.45pm BST on Wednesday, October 29, 2025
Venue: Emirates Stadium
How to watch: Sky Sports