Spurs are gearing up for the first north London derby of the season with as many as 13 first-team players out injured following Sarr’s early withdrawal against Brazil on Saturday.
The nature of the possible injury remains unclear but Sarr, who started the game, was accompanied off the pitch flanked by medical staff during the early stages of the second half.
Sarr’s possible absence for the derby, which takes place in eight days, would be another significant fitness blow for Spurs head coach Thomas Frank.
Spurs saw skipper Cristian Romero and loanee striker Randal Kolo Muani pick up injuries during the 2-2 draw with Manchester United last time out.
Star summer signing Mohammed Kudus missed that game after picking up a knock the week before.
Meanwhile, Lucas Bergvall was sent home early from Sweden duty due to ongoing issues following a concussion.
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The likes of Archie Gray, Ben Davies and Dominic Solanke continue to be monitored ahead of returns from injury, while Dejan Kulusevski and Radu Dragusin are nearing returns after serious knee injuries.
There remains uncertainty over when Yves Bissouma and Kota Takai will play their first competitive minutes of the season, while James Maddison is out for the foreseeable.
Brazil’s win over Senegal was equally damaging to Arsenal, who saw Gabriel forced off with an injury shortly before Sarr’s withdrawal.