Ruben Amorim's side have a point to prove after they were held to a 1-1 draw by West Ham in midweek and will hope to bounce back in style against the team at the bottom of the table. Wolves have taken just two points all season and are the only side without a league win in the current campaign.
United are hopeful they will have a star player back from injury for their trip to Molineux, while the home side are expected to be without five players after a fresh injury blow. Here is all the latest combined injury news and return dates for the match.
De Ligt missed the West Ham draw due to a small injury. He is expected to be back for the trip to face Wolves on Monday night.
1. Mattthijs De Ligt - 8 December vs Wolves (A)
De Ligt missed the West Ham draw due to a small injury. He is expected to be back for the trip to face Wolves on Monday night. | Manchester United via Getty Images
Dalot suffered a knock against West Ham in midweek but it is not believed to be a serious issue. He should be fit to start at Molineux.
2. Diogo Dalot - 8 December vs Wolves (A)
Dalot suffered a knock against West Ham in midweek but it is not believed to be a serious issue. He should be fit to start at Molineux. | Manchester United via Getty Images
Maguire is currently sidelined due to a thigh injury and is not expected to be back for the trip to face Wolves. He could be back later this month.
3. Harry Maguire - 15 December vs Bournemouth (H)
Maguire is currently sidelined due to a thigh injury and is not expected to be back for the trip to face Wolves. He could be back later this month. | Getty Images
Sesko is still out due to a knee injury he picked up last month. There is no indication of when he he might return to training but he is due back at some stage this month.
4. Benjamin Sesko - 21 December vs Aston Villa (A)
Sesko is still out due to a knee injury he picked up last month. There is no indication of when he he might return to training but he is due back at some stage this month. | Getty Images