Ruben Amorim's side were held to a disappointing draw at home to West Ham in midweek, while Wolves are still yet to win a league match this season and have taken just two points during the campaign.
United hope to have Diogo Dalot and Matthijs De Ligt fit for their trip to Molineux, while Harry Maguire and Benjamin Sesko are both expected to miss out due to injury. It could be the last match United have Noussair Mazraoui, Amad Diallo and Bryan Mbeumo available, with the club still unsure when they will be required to report for Africa Cup of Nations duty.
Here is how we think United should line up against Wolves.
Manchester United predicted line up vs Wolves
1. Manchester United predicted line up vs Wolves
Manchester United predicted line up vs Wolves | line-up builder Photo: line-up builder
Lammens is the first-choice goalkeeper and will keep his spot against Wolves.
2. GK - Senne Lammens
Lammens is the first-choice goalkeeper and will keep his spot against Wolves. | Manchester United via Getty Images
Mazraoui played better than Leny Yoro against West Ham and would deserve to start again.
3. CB - Noussair Mazraoui
Mazraoui played better than Leny Yoro against West Ham and would deserve to start again. | Manchester United via Getty Images
United hope to have De Ligt back and if he is fit then he has to start in central defence.
4. CB - Matthijs De Ligt
United hope to have De Ligt back and if he is fit then he has to start in central defence. | Manchester United via Getty Images