United are certain to be without Amad Diallo and Bryan Mbeumo due to their participation in the Africa Cup of Nations, while Casemiro is suspended after he picked up a yellow card against Bournemouth earlier in the week.
It means Amorim will have to find solutions to his side in both defensive midfield and on the right wing if United are to pick up three points this weekend. Villa go into the match on an incredible winning run and have already beaten both Arsenal and Man City at home this season.
Here is how we think United should line up at Villa Park.
Manchester United predicted line up vs Aston Villa
1. Manchester United predicted line up vs Aston Villa
Manchester United predicted line up vs Aston Villa | line-up builder Photo: line-up builder
Lammens made some big saves against Bournemouth and should start again.
2. GK - Senne Lammens
Lammens made some big saves against Bournemouth and should start again. | Manchester United via Getty Images
Yoro is crucial to United's backline as either a centre-back or right-back if they switch formation.
3. CB - Leny Yoro
Yoro is crucial to United's backline as either a centre-back or right-back if they switch formation. | Manchester United via Getty Images
Heaven has enjoyed a good run in the starting line up and should play there again this weekend.
4. CB - Ayden Heaven
Heaven has enjoyed a good run in the starting line up and should play there again this weekend. | Manchester United via Getty Images