The 41-year-old began his tenure with a 2-2 draw against Burnley in midweek in which he changed formation to a more familiar 4-2-3-1 approach. Fletcher is expected to deploy a similar set-up against Brighton this weekend and could freshen up his side with a few changes.
United welcomed back Bruno Fernandes, Mason Mount, Kobbie Mainoo and Harry Maguire from injury for the Burnley draw, while Shea Lacey also impressed from the bench. It has even been suggested that 15-year-old sensation JJ Gabriel could be named in the matchday squad, with him eligible to feature in FA Cup competition.
Here is how we think United will line up when they face Brighton at Old Trafford.
There is no need to change goalkeeper in the FA Cup and Lammens should keep his starting role.
1. GK - Senne Lammens
There is no need to change goalkeeper in the FA Cup and Lammens should keep his starting role. | Getty Images
Yoro has fallen down the pecking order recently and should be given a rare start in defence.
2. CB - Leny Yoro
Yoro has fallen down the pecking order recently and should be given a rare start in defence. | Getty Images
Shaw could move back into a centre-back role with Lisandro Martinez handed a rest from the start.
3. CB - Luke Shaw
Shaw could move back into a centre-back role with Lisandro Martinez handed a rest from the start. | Getty Images
Dalot is reliable and should have no problem with another start against Brighton.
4. RB - Diogo Dalot
Dalot is reliable and should have no problem with another start against Brighton. | Getty Images