Darren Fletcher is in charge of the youngsters, after his two-match stint as interim head coach of the first team, and he will be looking for his players to enjoy the experience of competing on the big stage again.
The tie must be decided on the night, with extra-time and penalties if required, and the victors have been drawn away to Oxford United or Colchester United in the fifth round.
That game is being played on Thursday night at the Kassam Stadium.