The commemorative fixture will take place at St Mary’s on Saturday, March 28, with Le Tissier taking charge of the Saints side and former United captain Robson leading the Man United Legends.
Two fan favourites will also return to St Mary’s in Saints colours, with José Fonte and Rickie Lambert bringing a combined total of 523 appearances for the club, while Man United’s line-up will include former Premier League winners Dimitar Berbatov and Louis Saha.
The Legends squads continue to grow, with Andrew Surman and Jos Hooiveld confirmed to line up for Saints, while Ronny Johnsen and Danny Simpson will represent the Red Devils.
Saints Legends will host a Man United Legends team in March (Image: Southampton FC)
Supporters attending the match will also have the chance to hear from members of the 1976 FA Cup-winning team during the afternoon, as they share memories from the famous Wembley victory.
Saints season ticket holders and members can purchase tickets at a discounted rate of £15 for adults and £5 for children until the end of January. General sale prices are £20 for adults and £10 for children.
Tickets are available in the Itchen and Northam stands, with away supporters accommodated in the Kingsland stand.
The event forms part of the club’s celebrations to mark 50 years since the club lifted the FA Cup for the first time in 1976, a landmark moment in Saints history.