Brighton and Hove Albion FC are set to play Crystal Palace at the Amex, in Brighton, on Sunday (February 8).
The clubs have a long standing rivalry which spans back to the early 1970s, when the two teams - once kept apart in the league ladder - began to play one another more.
The rivalry is sometimes nicknamed the M23 derby, referring to motorway which connects the teams.
Officers outside Wetherspoons during a game last year (Image: Annabel Stock)
Previous games in the city have seen an increased police presence, with officers positioned at the station, stadium, and outside the Wetherspoons in West Street.
Sussex Police said it has considered the rivalry in their planning and are working with Brighton and Hove FC to ensure public safety.
A spokeswoman for the force said: "Sussex Police assesses each event and football fixture against a national set of standards in coming to a decision on how to provide an appropriate policing response in support of the club.
"We are of course aware of the historic and existing rivalries between Brighton and Hove Albion and Crystal Palace. This is considered in our planning and resourcing for this particular game, which starts some months before the match.
"Sussex Police will support Brighton and Hove Albion Football Club in its operation, and work in conjunction with other emergency services to ensure everyone has a safe and enjoyable day.
"Security within the ground remains the responsibility of the club, supported by us."
It confirmed that a Public Space Protection Order is in place for Brighton city centre, and advised fans that alcohol outside of licensed premises, including from bottles and cans, can be seized and removed by officers.
It added: "There is likely be congestion and disruption to travel into the city, particularly near Brighton station.
"Residents and visitors using public transport or the road network are advised to allow extra travel time and to check updates with transport providers."