The winger replaces Chemsdine Talbi in the only change from the side that started against Arsenal at the weekend.
That means Nordi Mukiele, Dan Ballard, Omar Alderete and Reinildo continue in defence, with Trai Hume advanced on the right. Noah Sadiki, Habib Diarra and Enzo Le Fee are in midfield, Angulo on the left and Brian Brobbey leading the line.
Angulo made his debut from the bench in the weekend defeat at Arsenal, just five days after joining from Anderlecht.
Discussing the winger in his press conference on Tuesday, Regis Le Bris said: "He's ready to play. He's played a lot of football this year at a good level. He's ready."
Arne Slot has made two changes to his Liverpool team, with Endo replacing the suspended Dominic Szoboszlai at right-back and Andy Robertson coming in for Milos Kerkez at left-back.
SUNDERLAND: Roefs, Mukiele, Ballard, Alderete, Reinildo, Sadiki, Diarra, Le Fee, Hume, Angulo, Brobbey
SUBSTITUTES: Ellborg, Cirkin, O'Nien, Geertruida, Rigg, Mundle, Isidor, Mayenda, Talbi
LIVERPOOL: Alisson; Endo, Konate, Van Dijk, Robertson; Gravenberch, Mac Allister; Salah, Wirtz, Gakpo; Ekitike.
SUBSTITUTES: Mamardashvili, Gomez, Kerkez, Chiesa, Jones, Nyoni, Ramsay, Ngumoha, Morrison.