Stoke City and Fulham have previously met once before in the FA Cup, with the Cottagers winning 3-0 in the fourth round in January 2007 at Craven Cottage.
Fulham have progressed from each of their last seven FA Cup ties against sides from a lower division, since losing 2-1 at home to fourth tier Oldham Athletic in January 2019.
Stoke have progressed from five of their seven FA Cup fourth round ties played on home soil this century, though they were beaten in a penalty shoot-out by Cardiff City in this round last season at the bet365 Stadium after a 3-3 draw.
Fulham will be looking to reach the FA Cup fifth round for the second consecutive season, last achieving that feat in three seasons in a row between 2008-09 and 2010-11.
Stoke have won each of their last five home FA Cup ties against sides from London, scoring 13 goals in total during that time which includes a 2-0 victory vs Leyton Orient in their last such match at the third round stage in January 2022.