Tyler Adams will have had a period of full training after his return from injury to the bench at Everton last time out, while it was hoped that Marcus Tavernier may be ready for a return against the Hammers.
If both are back and there are no further issues in the squad, Andoni Iraola will have some tough choices to make and a senior player will likely have to miss out of the match day squad.
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But with the team on good form, will Iraola make any changes to the starting XI?
The Daily Echo predicts how the Cherries will line up on Saturday.
Goalkeeper
Djordje Petrovic has started every game so far this season, and despite the arrival of Christos Mandas on loan from Lazio, I would expect the Serbian to continue in between the sticks in the capital.
Defenders
It is a settled back line for Bournemouth, with the team’s form having turned since James Hill and Marcos Senesi partnered at centre back.
Both have been excellent recently, Hill in particular, and they will start again at the heart of defence.
(Image: Peter Byrne/PA Wire)
At left back, Adrien Truffert will continue, while Alex Jimenez, whose permanent move to the Cherries was confirmed since the win over Everton, will start at right back once again.
Midfielders
I do think once Tyler Adams is fully back to speed, he does come back into the side having been one of the early standouts in the Cherries season.
But the question is whether Iraola believes he is ready to start again after his injury with no minutes yet since his return.
I think the American will be on the bench at the London Stadium. Iraola has plenty of options in midfield – Alex Scott will start and it will be one of Lewis Cook, Ryan Christie and Alex Toth that starts alongside him, and I will go for Cook.
Forwards
Again, Iraola is blessed with options for his forward line, with players returning from injury.
Rayan has to start again after his superb start in a Cherries shirt, and fellow Brazilian Evanilson will continue at number nine.
(Image: Peter Byrne/PA Wire)
Amine Adli scored against Everton and he deserves the opportunity to start again, while Junior Kroupi was good off the bench against the Toffees and will come back into the XI.
Full team: Petrovic; Truffert, Senesi, Hill, Jimenez; Cook, Scott; Adli, Kroupi, Rayan; Evanilson.