That left Palace with over 25 minutes of normal time to find a breakthrough, as Wolves retreated to preserve a rare clean sheet.
Muñoz went close to getting on the end of Riad’s cross, only for a last-ditch challenge from Hugo Bueno to halt him at the last moment.
Evann Guessand was then introduced to proceedings as Glasner looked to unlock Wolves' defence, before Pino tested Sa with a free-kick.
It looked as if Palace had lost hope going into the dying minutes – following a lengthy stoppage after a clash between Chris Richards and Hugo Bueno, which had slowed any momentum.
But as the clock ticked to 90 minutes, the breakthrough finally arrived. Wharton showed composure and class to find Mitchell lurking on the left-wing.
His low cross found Guessand who produced a first-time finish that gave Sa no chance – Selhurst duly erupting.
There was still eight minutes of injury-time to get through and the Eagles should have had a second only for Jaydee Canvot to miss from only a few yards out.
In the end it didn't matter, as the Eagles saw out the remainder of injury-time with ease and secured a first home league win in 2026.
**Palace:** Henderson (GK), Riad (Guessand, 72), Richards, Canvot, Muñoz, Wharton, Hughes (Kamada, 46), Mitchell, Sarr, Strand Larsen, Pino (Johnson, 78).
**Subs:** Benítez (GK), Clyne, Sosa, Cardines, Devenny, Uche.
**Wolves:** Sa (GK), Tchatchoua, Mosquera (A Gomes, 92), S Bueno, Krejčí, H Bueno, Andre, Bellegarde (Jaoa Gomes, 87), Mane, Armstrong (Wolfe, 63), Arokodare.
**Subs:** Johnstone (GK), Doherty, Lima, T Gomes, Toti, J Gomes, Edozie.