Dutchman Botman, 26, has missed the last three games with a back problem and 29-year-old DR Congo international Wissa has been absent for four matches with a dead leg.
Both trained with a trimmed-down squad at the club’s blustery Benton base on Monday morning ahead of the play-off second leg against the champions of Azerbaijan on Tuesday evening.
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Key midfielder Sandro Tonali and in-form forward Anthony Gordon, however, were not among the group which were put through their paces by head coach Eddie Howe and his staff during the open part of the session, although given their workload in recent weeks, that is perhaps not surprising.
The Magpies ended a run of four successive away games in 12 days, one of them involving a 5,000-mile round trip to Baku, with Saturday night’s 2-1 Premier League defeat at Manchester City having won at Tottenham, Aston Villa and Qarabag in three different competitions.
A 6-1 rout at the Tofiq Bahramov Republican Stadium last Wednesday left Howe’s men with one foot firmly in the last 16 and with the option of resting some of his weary players, firm in the knowledge that it would take a disastrous turn of events to rob them of a next-round showdown with either Barcelona or Chelsea.