Nick Pope, Malick Thiaw, Lewis Hall, Jacob Ramsey, Anthony Elanga and Anthony Gordon come into the side, replacing Aaron Ramsdale, Sven Botman, Alex Murphy, Jacob Murphy, Will Osula and Harvey Barnes.
Kieran Trippier, Thiaw, Dan Burn and Hall make up the backline, but it's further forward where it will be intriguing to see how Newcastle set up.
Sandro Tonali and Ramsey will start in midfield but it's not clear whether they'll be joined by Joelinton or Nick Woltemade.
If it's the former, Woltemade looks set to start up-front with Elanga and Gordon on the flanks.
If it's the latter, Joelinton is likely to start on the left, with Elanga on the right and Gordon up front.
NEWCASTLE: Pope, Trippier, Thiaw, Burn, Hall; Tonali, Ramsey, Joelinton, Woltemade, Elanga, Gordon.
SUBS: Ramsdale, Botman, Barnes, Shahar, A Murphy, Willock, J Murphy, Wissa, Osula
EVERTON: Pickford, O'Brien, Tarkowski, Brathwaite, Mykolenko, Gana, Garner, Dewsbury-Hall, Ndiaye, Beto
SUBS: Travers, Patterson, Keane, Barry, George, Dibling, Rohl, Armstrong, Iroegbunam