Michael Carrick's side moved up to third in the table after another win over Crystal Palace at the weekend but were handed a double fitness scare when both Harry Maguire and Luke Shaw left the pitch in discomfort. It is not clear whether either of them will be available to start at St. James' Park in midweek.
United could therefore make some changes to their side against Newcastle, with Noussair Mazraoui a candidate to start after his impressive performance from the bench last time out. Benjamin Sesko will also hope to lead the line again after he netted another goal in the Palace win.
Here is how we think United should line up against Newcastle.
Lammens was solid against Palace and will start again in midweek.
1. GK - Senne Lammens
Lammens was solid against Palace and will start again in midweek. | Getty Images
Dalot is still the most reliable right-back at the club and should play.
2. RB - Diogo Dalot
Dalot is still the most reliable right-back at the club and should play. | AFP via Getty Images
Yoro is the obvious choice in defence with Lisandro Martinez still not fully fit.
3. CB - Leny Yoro
Yoro is the obvious choice in defence with Lisandro Martinez still not fully fit. | Getty Images
Maguire should be able to start again in midweek with a lengthy break after the match to recover.
4. CB - Harry Maguire
Maguire should be able to start again in midweek with a lengthy break after the match to recover. | Getty Images