Pope's error-strewn campaign continued at the weekend as he spilled Dwight McNeil's shot, enabling Beto to score Everton's second goal.
That was far from the first mistake the England international has made this season, and Howe has acted decisively by taking him out of the starting line-up, with Ramsdale handed a first league start since the defeat to Manchester United at Old Trafford in December.
Howe has made two changes to the side that started Saturday's 3-2 defeat to Everton, with Nick Woltemade also dropping out of the starting XI after suffering from illness this week.
Harvey Barnes returns to the starting side, and is set to line up on the left-hand flank with Anthony Gordon continuing as the central striker.
Jacob Ramsey retains his place in the side, having recovered from the illness that forced him off during the half-time break of Newcastle's weekend defeat.
Sven Botman and Yoane Wissa are on the substitutes' bench, but midfielder Lewis Miley is once again absent from the squad.
NEWCASTLE (4-3-3): Ramsdale; Trippier, Thiaw, Burn, Hall; Ramsey, Tonali, Joelinton; Elanga, Gordon, Barnes.
Subs: Pope, Botman, Wissa, Osula, J Murphy, Willock, A Murphy, Shahar, Neave.