With the battle for a top-three finish in the league heating up for Manchester United and the fight to avoid a relegation spot at the other end of the table for West Ham intensifying, the stakes are high for both sides heading into Wednesday's fixture.
Only two points separate West Ham from Leicester City, who currently sit in last place in the league, picking up points in the final five games of the season is essential if the Hammers want to be certain of securing their place in the top flight for next season.
Following defeat in the League Cup against Chelsea last weekend, Man United will be eager to pick themselves back up and turn their attention to securing a Champions League spot for next season. The match is likely to be no easy feat for the Red Devils, though, having been held to a 0-0 draw in this same fixture at the end of last season, and needing a moment of magic from Dominique Janssen to secure a narrow 2-1 victory over the Hammers at home in December.
West Ham
West Ham's captain, Katrina Gorry, will be unavailable for the fixture, alongside Riko Ueki, with both away competing at the Asian Cup for Australia and Japan, respectively.
Manchester United
Hinata Miyazawa, Man United's usually ever-present midfielder, is also competing at the Asian Cup and will not be available for selection tomorrow.
Ella Toone, Leah Galton and Anna Sandberg remain unavailable, with Marc Skinner confirming that he hopes to see Toone and Sandberg return for Man United's game against Tottenham at the end of April.
Skinner confirmed that Phallon Tullis-Joyce and Melvine Malard picked up knocks in the Red Devils' clash in the League Cup final last weekend, but he hopes that both will be available for the match against West Ham.
Predicted lineups
West Ham
Szemik; Endo, Hansen, Cascarino; Wandeler; Zelem, Siren, Hanshaw; Morgan, Martinez, Asseyi
Manchester United
Tullis-Joyce; Lundkvist, Le Tissier, Turner, Janssen; Zigiotti, Naalsund, Awujo; Park, Schüller, Malard
Key Players
West Ham United - Katie Zelem
Zelem will be a key player for West Ham. Her wealth of league experience alone makes her a dangerous presence in midfield, but facing former club Manchester United adds an extra dimension. Having captained Man United for five seasons, her insight and familiarity with the squad and manager heighten the threat she poses for Rita Guarino's side.
Zelem is a huge threat from set-pieces, holding the all-time record for set-piece assists in the WSL, whilst a weakness for Man United this season has been defending set pieces. These two factors combined could make all the difference in the match, and may be the key to success for the Hammers.
Manchester United - Jess Park
Man United were punished at the weekend in the League Cup final for not taking their chances against Chelsea, and it is important that they do not make the same mistake if they want to keep pace in the race for top three in the league. With six goals and four assists in the WSL alone this season, Jess Park's first season in red could not have gone much better so far.
Having proved that she is capable of scoring brilliant individual goals, often dribbling through defenders and taking shots from distance, Park has been the perfect attacking outlet for Skinner's side on many occasions. The Red Devils will be hoping that Park can continue her fine run of form in tomorrow's fixture.
Match Details
The match will take place at the Chigwell Construction Stadium, Dagenham.
Kick off is at 19:15 GMT.
The game will be streamed on BBC Three.