Unai Emery's side will be looking to complete the job at Villa Park on Thursday - and book their spot in the quarter-finals of the Europa League.
And a statistic has emerged that bodes well for Villa, but not so much for their opponents.
Statistics show that Lille have never won an away match against an English side in a major European competition in nine attempts, with one draw and eight defeats.
Their first visit was for a 1-0 defeat against Manchester United way back in 2001 - with the French side drawing a group stage match against United in 2005.
Fast forward to 2007 and they were beaten narrowly again at Old Trafford in the quarter-finals with Henrik Larsson firing in the winner for United.
They were beaten twice at Liverpool, one coming in 2010. Fernando Torres scored a brace and former Villa boss Steven Gerrard netted for Liverpool in a 3-0 win in the last eight of the Europa League.
In 2014, they were again beaten on Merseyside as they went down 3-0 against Everton in the Europa League group stages, with a visit to Chelsea in December 2019 ending in a 3-0 defeat. That was one of two defeats against the Blues.
They were also beaten at Villa park back in 2014 in the Conference League, with Emery's side running out 2-1 winners.