Lyon 0–2Celta Vigo (first leg 1–1)
61' Rueda (C), 90+2' Jutgla (C)
Freiburg v Genk 5-2 (first leg 0-1)
19' Ginter (F), 25' Matanovic (F), 39' Smets (G), 53' Grifo (F), 56' Suzuki (F), 79' Eggestein (F)
Midtjylland vNottingham Forest 1-2 (0-3 on penalties) (first leg 1-0)
40' Dominguez (N), 52' Yates (N), 69' Erlic (M)
Aston Villa v Lille 2-0 (first leg 1-0)
54' McGinn (A), 86' Bailey (A)
Betis v Panathinaikos 4-0
8' Ruibal (B), 45' Amrabat (B), 53' Hernandez (B), 66' Antony (B)
Porto v Stuttgart 2-0
21' Gomes (P), 72' Froholdt (P)