And it would be a surprise if either were in the starting XI for today's Tyne-Wear derby against Sunderland.
Wissa has endured a miserable first season on Tyneside, is clearly still playing catch-up after the knee injury that severely delayed his debut and has played just 15 minutes of Newcastle's last five Premier League games.
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As for Woltemade, the record recruit enjoyed a fine start in black and white but has lost momentum and his place in the side as a striker, instead being used as a midfielder. Germany boss Julian Nagelsmann this week admitted his striker's situation at his club "bothers him".
If Sandro Tonali is fit for today's game, Woltemade will almost certainly have to miss out and it would be a huge surprise if Wissa was in the starting XI.
"Every player wants to play the biggest games," said Howe of the pair.
"Nick has had a lot of football this year. I thought he played really well against Chelsea.
"They're in different circumstances. I wouldn't put them together.
"Yoane has had a big injury and I've said many times here I don't think we've seen the best of him yet. Hopefully that will come. I'd look at them independently rather than together.
"They both have big parts to play in the close of this season. We have eight massive games to go. We now only have the Premier League to focus on. Collectively we have to focus on the rest of the season."
How Woltemade would love to get the chance to make amends today for his own-goal in the December derby, the decisive moment at the Stadium of Light.
"Nick dealt really well with it. It's tough for any player to go through that," said Howe.
"His character is amazing. I really enjoy working with him, he's a really special guy, he has great qualities, he's very positive.
"Even in difficult moments like that one, even in challenging moments like in recent weeks where he's not played as much as he wants he's been first class, he's trained really well.
"He'll be ready to take the pitch and do his best for the team. He has the quality to make the difference."