The break includes important World Cup play-offs, as the final slots for the big summer tournament are due to be filled next week.
Other nations are fine-tuning their plans for the event in the United States, Canada and Mexico as the focus switches to international football, while domestic matters pause for a spell.
Michael Carrick's Reds are not back in action until Monday 13 April, when we welcome Leeds United to Old Trafford for a 20:00 BST kick-off.