But it will be a tough ask for the Wearsiders, with Tanya Oxtoby's visitors still very much in the race to win promotion to WSL this season.
While Sunderland's men have a glorious derby record against their near neighbours, it's been a different story for the women's side, who have lost all three derbies since Newcastle's promotion.
But Sunderland will be buoyed by their win over bottom club Portsmouth last week, which all but secured their own status in WSL2, and boss Mel Reay now wants to taste derby success at the Stadium of Light.
She said: "We're conscious that we're going to be playing in front of the biggest home crowd of the season at the Stadium of Light.
"We want to entertain the fans and we want to make them proud of the result - we know they're proud of the team because of the turnout week in, week out at Eppleton but there's no hiding from the magnitude of the game. It's a local derby, we're well aware of that. We know we haven't won one yet.
"It's important. We have to try and grow the game, we have to try and grow the crowds. And we know that we can do that by good performances. Fans will come back, there'll be loads of new fans in the stadium who've maybe not watched the team for a while. You want to hook them in and you hook them in by playing well and getting points - we know winning this game will help."
Newcastle are fourth, just a point behind Crystal Palace, who occupy the play-off spot, and four points behind Birmingham in the second automatic promotion place.
Beth Lumsden said: "Playing Sunderland makes it that bit bigger. Every game we need to win now for us getting where we want to be.
"But coming up against Sunderland creates a little bit more excitement. We've played them three times and beat them three times, so a fourth would be a nice bit to add on."
Lumsden added: "We'll prepare the same as we do every other game. I know that's cliché to say but you have to try and take the emotions out of it and the occasion out of it, and just stick to the game plan and try and get the three points at the end of it.
"Then, when you do get three points at the end, you enjoy the moment, the atmosphere and the occasion."