Michael Carrick's side will have enjoyed a lengthy break before they are back in action, and could see their line up boosted by the return of some key players. Lisandro Martinez and Noussair Mazraoui could both be in contention after recent injury issues, while Bryan Mbeumo and Benjamin Sesko should be available after they withdrew from international duty.
United will get a clearer picture of their fitness levels when they travel to the Republic of Ireland on Monday for an intensive training camp in Dublin. Here is an early look at the playing squad they are likely to have and how we expect them to line up against Leeds next time out.
Lammens has enjoyed a good debut season and will keep his place in goal.
1. GK - Senne Lammens
Lammens has enjoyed a good debut season and will keep his place in goal. | Getty Images
Dalot is the obvious choice to start at right-back after a solid season.
2. RB - Diogo Dalot
Dalot is the obvious choice to start at right-back after a solid season. | Getty Images
Yoro should start at centre-back with Harry Maguire suspended for the clash.
3. CB - Leny Yoro
Yoro should start at centre-back with Harry Maguire suspended for the clash. | Getty Images
Martinez will hope to be fit enough for a place in the starting line up.
4. CB - Lisandro Martinez
Martinez will hope to be fit enough for a place in the starting line up. | Getty Images