Sunday's game will come too soon for Dan Ballard, but Regis Le Bris hinted that the centre-half might be back for next week's trip to Aston Villa. Nilson Angulo is also making good progress and is expected to soon be in contention to return.
But Le Bris admits Romaine Mundle and Jocelin Ta Bi could be missing until the end of the season.
If the pair make good progress, they could be in contention to return in the final week or so of the campaign, but even if that was the case Le Bris would be reluctant to risk the wingers.
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Bertrand Traore will again be missing on Sunday but he's in line to return to action sooner than fellow wingers Mundle and Ta Bi. Simon Moore also has an injury, but with Roefs available again, the deputy keeper would have dropped out of the squad anyway.
Roefs has missed the last three Sunderland games with a hamstring injury he suffered in the draw at Bournemouth.
Mukiele, Le Fee and Reinildo were all in the squad for the derby win over Newcastle before the break but none were deemed ready to start.
But the break has done the trio the world of good and Le Bris must now decide whether to restore them to the line-up tomorrow.
Le Bris said: "They are all ready to start. They’re ready physically to compete in the Premier League."
Updating on the rest of the injuries, Le Bris said: "For the players, we have Jocelin, Romaine, Bertrand and Simon sidelined for this game.
"For Ballard and Nilson, they are close to returning back but it will be a bit short for Tottenham. For the rest of the group, they are available."
Ballard was forced off in the win over Brighton and missed the derby, while January recruit Angulo has missed the last two games.
Le Bris said: "Sometimes you might think you can take risks but if the player gets a new injury it might take a long time after the second injury.
"We haven't rushed the process and it won't be the case for Ballard and Nilson in this situation."
Ta Bi picked up his injury shortly after his January arrival, while Mundle suffered another serious hamstring injury, similar to last summer's but on the other leg. It's why Le Bris is keen to stress the need for caution with the winger.
Le Bris said: "Probably for Jocelin and Romaine, it will be at the end of the season.
"It might be the last week, so we won't take risks to play with them if they are not ready. Probably it will be more to prepare them properly to be ready for the pre-season, in good shape. For Bertrand, it might be a bit earlier."