The fit again Targett replaces the injured Alex Bangura, with Dael Fry coming into the defence in place of Luke Ayling, who drops to the bench.
Sammy Silvera is back among the substitutes but Boro are again without Hayden Hackney, Morgan Whittaker and Leo Castledine.
Jeremy Sarmiento keeps his place in the side, with Sontje Hansen and Kaly Sene again among the substitutes.
Sol Brynn is in goal for Boro, with Callum Brittain, Fry, Adilson Malanda and Targett in defence.
Alan Browne and Aidan Morris are in midfield, with Riley McGree and Sarmiento supporting David Strelec and Tommy Conway.
John Mousinho has made two changes to his Portsmouth side.
MIDDLESBROUGH: Brynn, Brittain, Fry, Malanda, Targett, Morris, Browne, McGree, Sarmiento, Strelec, Conway
SUBS: Wildsmith, Ayling, Gilbert, Munroe, Sene, Silvera, Edmundson, Hansen, Ibeh
PORTSMOUTH: Schmid; Devlin, Poole, Dia, Williams; Pack (c), Dozzell; Caballero, Chaplin, Anderson; Bishop
SUBS: Bursik, Shaughnessy, Bowat, Le Roux, Swift, Segečić, Alli, Blair, Waddingham