Tickets are still available for the 19:00 BST kick-off, which is being shown live on TNT Sports. Highlights will be follow on MUTV, ManUtd.com and the United App.
They are priced at £10 for adults and £5 for under 16s, and the contest must be decided on the night, with extra-time and penalties, if required.
The Reds have a rich history with Palace in the competition, after beating them in the 1991/92 two-legged final, when a number of the famed Class of '92 first rose to wider prominence.
We also overcame the Eagles in the fifth round in 2006/07 and in late 2022, when winning 3-1 at Selhurst Park.